CBD, or Cannabidiol, is a product derived from the cannabis plant. This ingredient is very popular in the supplement industry because of its benefits to the body and mind. It is considered to be safe and unlikely to cause unwanted side effects.
However, it is important to note that CBD can interact with certain drugs and pharmaceuticals, which can lead to serious side effects. Therefore, it is advisable to consult your doctor before taking CBD, especially if you are already taking medications. In this article, we will look at the medications that should not be taken with CBD.
What types of medications should not be taken with CBD?
According to a July 2021 study published at: https: //www.ncbi.nlm.nih.gov/pmc/articles/PMC8298645/, CBD may have numerous drug interactions, particularly involving liver metabolism. While prescribing information is often used to identify potential drug interactions, it may be limited in scope and accuracy, particularly with respect to the therapeutic use of cannabis and medicinal cannabinoids that do not have regulator-approved prescribing information. Thus, the objective of the study described in the text was to provide a comprehensive and detailed list of drug interactions involving cannabinoids. In addition to the list of drug interactions, the article also provides a list of 57 prescription drugs that could potentially be affected by concomitant cannabinoid use.
Drugs that should not be taken with CBD include:
Medications containing THC or synthetic cannabinoids
Taking CBD with medications containing THC or synthetic cannabinoids at the same time can also lead to potentially dangerous interactions. THC and synthetic cannabinoids may have similar effects to CBD, but they may also act differently in the body and interact with medications in unexpected ways.
If you are taking medications containing THC or synthetic cannabinoids, it is important to talk to your doctor before taking CBD, as there may be potential interactions that can affect the effectiveness or safety of your medications.
Opiate and opiate derivative medications (including codeine, oxycodone, etc.)
Taking CBD and opiate-based medications can also lead to potentially dangerous interactions. CBD can interact with opioids in different ways, which can increase the risk of adverse side effects or decrease the effectiveness of opioids.
CBD can increase the sedative effects of opioids, which can lead to excessive drowsiness and decreased alertness. This can increase the risk of accidents or falls, especially in the elderly.
Additionally, CBD can interfere with the way some opioids are metabolized in the liver, which can increase the level of opioids in the body, leading to increased side effects, such as nausea, constipation, drowsiness, respiratory depression and addiction.
Medications to treat anxiety and depression
Antidepressants are medications used to treat depression and other mood disorders. Cannabidiol (CBD) is a compound derived from hemp that is often used for its anti-anxiety and anti-stress effects. It is important to note that CBD can interact with medications, including antidepressants.
CBD is metabolized in the liver by the cytochrome P450 (CYP450) enzyme system, and some antidepressants are also metabolized by this enzyme system, which can lead to drug interactions. When CBD inhibits CYP450 enzymes, it can lead to increased blood levels of antidepressants and increase the risk of side effects.
Therefore, if you are taking antidepressants and are considering taking CBD, it is important to consult with a healthcare professional to discuss the potential risks and benefits. Your doctor can help you adjust the dose of your medications or closely monitor potential side effects if you decide to take CBD.
Medications containing monoamine oxidase inhibitors (MAOIs)
MAOIs are a class of drugs used to treat depression and other psychiatric disorders. They work by inhibiting the enzyme monoamine oxidase, which breaks down neurotransmitters such as dopamine, norepinephrine and serotonin in the brain.
CBD, or cannabidiol, is a cannabinoid derived from cannabis. It is used to treat epilepsy, anxiety, pain and other health conditions. CBD works by modulating cannabinoid receptors in the nervous system.
There are few studies on the interactions between MAOIs and CBD, but it is possible that the two substances can interact in a negative way. MAOIs can increase the levels of certain neurotransmitters in the brain, and CBD can increase or decrease the activity of certain neurotransmitter receptors.
If you are taking MAOIs, it is important to talk to your doctor before taking CBD or any other cannabis product. Your doctor will be able to advise you on the potential risks and benefits of using CBD, as well as any dosage adjustments needed to avoid negative interactions. It is important not to stop or change the dosage of your prescribed medications without your doctor’s advice.
Certain antibiotics and antiviral drugs
There are still few scientific studies that have looked at the interaction between CBD and antibiotics / antivirals. However, it is important to note that CBD can affect the metabolism of some drugs by inhibiting certain liver enzymes that are responsible for drug metabolism. This can lead to a buildup of drugs in the body, which can increase side effects and the risk of intoxication.
In addition, some antibiotics such as rifampin and griseofulvin, and some antivirals such as ritonavir and saquinavir, can increase the activity of these enzymes, which can decrease the effectiveness of CBD.
Therefore, it is important to discuss with your doctor the use of CBD in combination with antibiotics or antiviral medications, especially if you are taking high doses of CBD or have underlying medical conditions. Your doctor will be able to advise you on the appropriate dosage of CBD and monitor any potential side effects.
Medications to control cholesterol and reduce the risk of heart disease
Cholesterol is an important fatty substance in the body, but high levels of cholesterol in the blood can increase the risk of heart disease. To control cholesterol and reduce the risk of heart disease, the most commonly used medications are statins, fibrates and cholesterol absorption inhibitors.
Regarding potential interactions between these drugs and CBD (cannabidiol), preliminary studies have suggested that CBD may affect liver function, which is important for drug metabolism.
Specifically, some research has shown that CBD can inhibit certain liver enzymes, which can increase the blood levels of certain drugs, including statins, fibrates and cholesterol absorption inhibitors. This can potentially increase the risk of side effects associated with these medications.
It is important to remember that there are other medications that can interact with CBD and it is imperative to discuss with your doctor before taking any type of medication.
How do drug interactions work?
When CBD is taken with certain types of medications, it can eliminate or reduce the effectiveness of the medication in question. This usually occurs when CBD interferes with the metabolism of a drug and reduces its bioavailability. For example, CBD can slow down the enzymes responsible for metabolizing drugs and disrupt their absorption into the body.
In addition, CBD can stimulate the endocannabinoid system and interfere with the action of drugs. For example, some THC-based drugs work by activating the CB1 and CB2 receptors of the endocannabinoid system. If a person takes CBD at the same time, it can interfere with the process and reduce the effectiveness of the medication.
What are the risks of drug interactions?
Drug interactions can cause unwanted side effects and increase the risk of medical complications. Because of CBD’s effects on drug metabolism and the endocannabinoid system, patients taking medications should not consume CBD without talking to their doctor.
The possible side effects of drug interactions can vary depending on the drugs involved and how they interact. Some of the common side effects associated with drug interactions include:
- Nausea and vomiting.
- Fatigue and drowsiness.
- Headaches and dizziness.
- Decreased appetite and weight loss.
- Dizziness and confusion.
- Irritability and restlessness.
- Difficulty breathing.
When to consult a doctor?
If you are taking a medication and want to take CBD, consult a doctor before doing so. Your doctor will be able to tell you about the potential risks and benefits, and whether CBD is right for you.
Your doctor will also be able to recommend an appropriate dosage and advise you on the best ways to take CBD to minimize the risk of drug interactions. In addition, your doctor can monitor your symptoms and responses to treatment to ensure you are receiving the most effective care.
While CBD is considered safe and beneficial for many health conditions, it’s important to understand that CBD can interact with certain medications. Medications not to take with CBD include those containing THC and synthetic cannabinoids, opiates, antidepressants, MAOIs, antibiotics, and cholesterol control medications. Drug interactions can lead to unwanted side effects and medical complications.
If you are taking any medication and are considering CBD, consult your doctor. Your doctor can help you find the right dosage and guide you to the best treatment.